Evaluation of Tumor Necrosis Factor-Alpha Gene (?308 G/A, ?238 G/A and ?857 C/T) Polymorphisms and the Risk of Gastric Cancer in Eastern Indian Population
نویسندگان
چکیده
Introduction: Gastric cancer (GC) is one of the leading causes cancer-related decimations worldwide. The gastric infection at both stomach and duodenum with Helicobacter pylori inflammation by tumor necrosis factor-alpha (TNF-?). aim study was to associate evaluate three TNF-? gene polymorphisms positions ?308 G/A, ?238 ?857 C/T risk GC. Methods: A total 156 individuals (consecutively diagnosed 95 GC patients 61 controls) above age 18 years were enrolled in study. Healthy normal upper gastrointestinal endoscopy (UGIE) irrespective their family history or peptic ulcer included as controls. cited evaluated using polymerase chain reaction-restriction fragment length polymorphism (RFLP). Results: There no significant difference distribution genetic factors, TNF-??308 GA/AA (22.1% vs. 14.8%, p = 0.2), TNF-??238 (21% 19.6%, 0.8), TNF-??857 CT/TT (8.4% 11.5%, 0.5), between cases healthy subgroup analysis H. pylori-positive showed that there (15(45.5%) 3(23%); 0.17) (12(36.3%) 2(15.4%); 0.17), TT/CT (13(39.4%) 0.13), among Conclusion: statistical comparisons GG genotypes (with OR 1.6, 95% CI: 0.6–3.8), (OR 1.09, 0.4–2.4) CC 0.7, 0.2–2.1) did not suggest any association population herein. Hence, (?308 G/A C/T) may be associating factor for incidence determined PCR–RFLP method.
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ژورنال
عنوان ژورنال: Gastroenterology Insights
سال: 2022
ISSN: ['2036-7422', '2036-7414']
DOI: https://doi.org/10.3390/gastroent13040034